Technology relates to a chemo enzymatic process for the stereo selective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile and their effective application in the preparation of (R)-GABOB through an enantioconvergent process comprising transesterifying 3-hydroxy-4-trityloxybutanenitrile, transforming optically pure 3-acetyloxy-4-trityloxybutanenitrile to (R)-GABOB and transforming 3-hydroxy-4-trityloxybutanenitrile to (R)-GABOB.
Patent Application Number: 7374926 , Granted EP, Indian and JP patent.
For more details about technology: Click here