Stereo-selective preparation of 3-hydroxy-3-(2-thienyl) propanenitrile

Stereo-selective preparation of 3-hydroxy-3-(2-thienyl) propanenitrile

Technology relates to a Chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile, which are optically pure intermediates for the synthesis of both enantiomers of duloxetine in high enantiomeric excess.
Status of Patent: US Patent 7045341 , Granted Indian and EP Patent.