Stereo-selective preparation of 3-hydroxy-3-Phenylpropionitrile

Stereo-selective preparation of 3-hydroxy-3-Phenylpropionitrile

Technology relates to a Chemoenzymatic process for the stereoselective preparation of both (R) and (S) enantiomers of 3-hydroxy-3-phenylpropanenitrile, useful as a key intermediate for synthesis of (S)-Fluoxetine, (R)-Tomoxetine and cognant compounds.
Status of Patent: PCT Application WO/2002/057475, Granted Indian and UK Patent and pending JP Patent.