Tablets with Enhanced Dissolution Rate

Tablets with Enhanced Dissolution Rate

The present technology provides tablets with enhanced dissolution rate of sparingly soluble drugs leading to increased bioavailability. Grains of solid dispersion of the drug in water soluble carrier are formed/cemented into tablets in a manner similar to that of cube sugar. Solid dispersions of drugs in carriers of poor compressibility can be easily formed into tablets of any suitable shape/size by known cube sugar technology. Resulting tablets are not only readily dispersible owing to capillary action but also ensure rapid dissolution of poorly soluble drug because of solid dispersion. Simultaneous exploitation of well-known approaches- solid dispersion, capillary action, optional surfactant and optional size reduction in the proposed technique results in steep enhancement of dissolution rate without compromising with content uniformity.
Status of Patent: Indian Patent Granted