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Chemoenzymatic Process For Stereoselective Preparation Of (R)-GABOB

Technology relates to a chemo enzymatic process for the stereo selective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile and their effective application in the preparation of (R)-GABOB through an enantioconvergent process comprising transesterifying 3-hydroxy-4-trityloxybutanenitrile, transforming optically pure 3-acetyloxy-4-trityloxybutanenitrile to (R)-GABOB and transforming 3-hydroxy-4-trityloxybutanenitrile to (R)-GABOB.

Patent Application Number: 7374926 , Granted EP, Indian and JP patent.

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