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Stereo-Selective Preparation Of 3-Hydroxy-3-(2-Thienyl) Propanenitrile

Technology relates to a Chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile, which are optically pure intermediates for the synthesis of both enantiomers of duloxetine in high enantiomeric excess.


Patent Number: 7045341, Granted Indian and EP Patent.

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